We just posted a new pre-print to bioRxiv. on the role of physical modeling in the future of structural biology. The abstract is below:
Heuristics based on physical insight have always been an important part of structure determination. However, recent efforts to model conformational ensembles and to make sense of sparse, ambiguous, and noisy data have revealed the value of detailed, quantitative physical models in structure determination. We review these two key challenges, describe different approaches to physical modeling in structure determination, and illustrate several successes and emerging technologies enabled by physical modeling.
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